Stress-induced hyperthermia: Effects of acute and repeated dosing of MPEP

• Published in: European journal of pharmacology Vol. 568; no. 1; pp. 199 - 202
• Main Authors: Nordquist, Rebecca E., Durkin, Sean, Jaeschke, Georg, Spooren, Will
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 30.07.2007; Elsevier
• Subjects: Animals; Anti-Anxiety Agents - administration & dosage; Anxiety - drug therapy; Anxiety - physiopathology; Biological and medical sciences; Chronic; Excitatory Amino Acid Antagonists - administration & dosage; Fever - drug therapy; Fever - physiopathology; Male; Medical sciences; Metabotropic glutamate receptor; mGlu5; Mice; Mice, Inbred Strains; Pharmacology. Drug treatments; Pyridines - administration & dosage; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate - antagonists & inhibitors; Stress, Psychological - complications; Stress-induced hyperthermia; Stress-induced hyperthermia; Chronic; mGlu5; Metabotropic glutamate receptor; Metabotropic receptor; Acute; Glutamate receptor; Induced hyperthermia; Stress
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/j.ejphar.2007.04.034

The mGlu5 receptor antagonist 2-methyl-6-(phenylethylnyl)-pyridine (MPEP) is highly anxiolytic in rodent models of anxiety. Recent studies showed that MPEP remains effective in some models of anxiety after repeated treatment, but tolerance may develop in other models. To further evaluate anxiolytic properties of repeated MPEP, a single administration of 3, 10, or 30 mg/kg p.o. and repeated administration of 30 mg/kg p.o. was tested in the stress-induced hyperthermia model in mice. MPEP dose-dependently inhibited stress-induced hyperthermia when given acutely. MPEP remained equally active in reducing stress-induced hyperthermia after five daily treatments with 30 mg/kg, further validating MPEP as a potential anxiolytic for chronic use.