Osthole suppresses seizures in the mouse maximal electroshock seizure model

• Published in: European journal of pharmacology Vol. 607; no. 1; pp. 107 - 109
• Main Authors: Luszczki, Jarogniew J., Andres-Mach, Marta, Cisowski, Wojciech, Mazol, Irena, Glowniak, Kazimierz, Czuczwar, Stanislaw J.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.04.2009; Elsevier
• Subjects: Animals; Anticonvulsants - administration & dosage; Anticonvulsants - pharmacology; Biological and medical sciences; Coumarins - administration & dosage; Coumarins - pharmacology; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Injections, Intraperitoneal; Male; Maximal electroshock seizure test; Medical sciences; Mice; Nervous system (semeiology, syndromes); Neurology; Osthole; Pharmacology. Drug treatments; Seizures - drug therapy; Time Factors; Osthole; Maximal electroshock seizure test; Nervous system diseases; Epilepsy; Rodentia; Cerebral disorder; Vertebrata; Mammalia; Convulsion; Mouse; Animal; Central nervous system disease; Models; Neurological disorder
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/j.ejphar.2009.02.022

The aim of this study was to determine the anticonvulsant effects of osthole {[7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one] – a natural coumarin derivative} in the mouse maximal electroshock-induced seizure model. The antiseizure effects of osthole were determined at 15, 30, 60, and 120 min after its systemic (i.p.) administration. Time course of anticonvulsant action of osthole revealed that the natural coumarin derivative produced a clear-cut antielectroshock activity in mice and the experimentally-derived ED 50 values for osthole ranged from 259 to 631 mg/kg. In conclusion, osthole suppresses seizure activity in the mouse maximal electroshock-induced seizure model. It may become a novel treatment option following further investigation in other animal models of epilepsy and preclinical studies.