Neurotransmitter dysfunction in patients with borderline personality disorder

Neurotransmitter system dysfunction may contribute to the borderline personality disorder traits of impulsive aggression and affective instability. This article reviews evidence from neurochemical assays, receptor-density studies, neuroendocrine-challenge paradigms, functional neuroimaging studies,...

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Bibliographic Details
Published inThe Psychiatric clinics of North America Vol. 23; no. 1; p. 27
Main Authors Gurvits, I G, Koenigsberg, H W, Siever, L J
Format Journal Article
LanguageEnglish
Published United States 01.03.2000
Subjects
Acetylcholine - metabolism
Affect
Aggression
Animals
Arginine Vasopressin - metabolism
Borderline Personality Disorder - metabolism
Borderline Personality Disorder - physiopathology
Brain - metabolism
gamma-Aminobutyric Acid - metabolism
Humans
Impulsive Behavior - metabolism
Neurotransmitter Agents - metabolism
Norepinephrine - metabolism
Serotonin - metabolism
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Summary:Neurotransmitter system dysfunction may contribute to the borderline personality disorder traits of impulsive aggression and affective instability. This article reviews evidence from neurochemical assays, receptor-density studies, neuroendocrine-challenge paradigms, functional neuroimaging studies, and candidate-gene research, which converge to identify particular neurotransmitter systems that seem to be dysregulated in patients with borderline personality disorder.
ISSN:0193-953X
DOI:10.1016/S0193-953X(05)70141-6