Subcutaneous administration of nimodipine improves bioavailability in rabbits
We compared subcutaneous and oral methods of nimodipine administration to determine a method of nimodipine administration that maintained serum levels at or above the optimal therapeutic concentration (7 ng/ml). Plasma concentrations of nimodipine were measured in New Zealand White rabbits (2.6–3.9...
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Published in | Journal of neuroscience methods Vol. 139; no. 2; pp. 195 - 201 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
30.10.2004
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Subjects | |
Online Access | Get full text |
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Summary: | We compared subcutaneous and oral methods of nimodipine administration to determine a method of nimodipine administration that maintained serum levels at or above the optimal therapeutic concentration (7
ng/ml). Plasma concentrations of nimodipine were measured in New Zealand White rabbits (2.6–3.9
kg). First, peak plasma concentration (
C
max), time to reach peak plasma concentration (
T
max), and area under the curve (AUC) parameters were calculated and compared between animals receiving oral or subcutaneous nimodipine (5–15
mg/kg). Next, plasma concentrations were measured 24
h after subcutaneous administration of 2.5
mg/kg of nimodipine in healthy animals and animals with experimentally induced SAH.
C
max,
T
max and AUC parameters were significantly greater for subcutaneous compared to oral nimodipine administration, irrespective of dose. Mean nimodipine concentrations at 24
h were >7
ng/ml in both healthy animals (12.9 ± 10.0
ng/ml) and in animals with SAH (11.8 ± 4.6
ng/ml) that received 2.5
mg/kg of subcutaneous nimodipine. In this model, the subcutaneous method of nimodipine administration consistently maintains plasma levels at or above the optimal therapeutic concentration, whereas oral administration fails to do so. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0165-0270 1872-678X |
DOI: | 10.1016/j.jneumeth.2004.04.030 |