Mechanism of Spaceflight-Induced Changes in Left Ventricular Mass

Decrements in left ventricular (LV) mass observed after microgravity exposure have been previously postulated to be a central component of spaceflight-induced cardiovascular deconditioning. In this study, echocardiographic measurements of LV mass in astronauts demonstrated a comparative 9.1% reducti...

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Bibliographic Details
Published inThe American journal of cardiology Vol. 95; no. 9; pp. 1128 - 1130
Main Authors Summers, Richard L., Martin, David S., Meck, Janice V., Coleman, Thomas G.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2005
Elsevier Limited
Subjects
Adult
Cardiology
Case-Control Studies
Dehydration - complications
Echocardiography
Female
Heart
Humans
Hypovolemia - etiology
Male
Middle Aged
Prospective Studies
Space biology
Space Flight
Space life sciences
Time Factors
Ventricular Remodeling - physiology
Weightlessness - adverse effects
NASA Discipline Cardiopulmonary
NASA Center JSC
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Summary:Decrements in left ventricular (LV) mass observed after microgravity exposure have been previously postulated to be a central component of spaceflight-induced cardiovascular deconditioning. In this study, echocardiographic measurements of LV mass in astronauts demonstrated a comparative 9.1% reduction in postflight LV mass that returned to preflight values by the third day of recovery. A ground-based study in normal subjects determined that these pre- to postflight LV mass changes could be reproduced by simple dehydration. Reductions in LV mass observed immediately after spaceflight may be secondary to simple physiologic fluid exchanges.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2005.01.033