Age estimation in dental pulp DNA based on human telomere shortening

Age estimation based on evidence found in teeth has received considerable attention within the field of forensic science. We determined the terminal restriction fragment (TRF) length, as telomere length, to estimate age. Using dental pulp DNA we found the average TRF length showed a tendency to shor...

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Bibliographic Details
Published inInternational journal of legal medicine Vol. 117; no. 4; pp. 232 - 234
Main Authors Takasaki, Tomoya, Tsuji, Akiko, Ikeda, Noriaki, Ohishi, Masamichi
Format Journal Article
LanguageEnglish
Published Germany Springer Nature B.V 01.08.2003
Subjects
Age
Aging - genetics
Aging - physiology
Cell division
Dental pulp
Dental Pulp - cytology
DNA - genetics
Forensic pathology
Forensic Sciences
Humans
Japan
Molecular weight
Phosphatase
Poisoning
Teeth
Telomere - genetics
Telomere - physiology
Yeast
Japan
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Summary:Age estimation based on evidence found in teeth has received considerable attention within the field of forensic science. We determined the terminal restriction fragment (TRF) length, as telomere length, to estimate age. Using dental pulp DNA we found the average TRF length showed a tendency to shortening with aging. Our findings show that telomere shortening, based on dental pulp DNA is a new and useful approach to estimate age of the subject at the time of death.
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ISSN:0937-9827
1437-1596
DOI:10.1007/s00414-003-0376-5