Potential therapeutic interventions of plant–derived isoflavones against acute lung injury

• Published in: International immunopharmacology Vol. 101; no. Pt A; p. 108204
• Main Authors: Aboushanab, Saied A., El-Far, Ali H., Narala, Venkata Ramireddy, Ragab, Rokia F., Kovaleva, Elena G.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2021; Elsevier BV
• Subjects: Acute lung injury; Acute Lung Injury - drug therapy; Animals; Anti-inflammatory; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - therapeutic use; Antioxidants; Bioactive compounds; Chemokines; Cytokines; Humans; Immunomodulation; Immunomodulatory; Inflammation; Isoflavones; Isoflavones - isolation & purification; Isoflavones - therapeutic use; Literature reviews; Lungs; Molecular modelling; Morbidity; MyD88 protein; NF-κB protein; Phytoestrogens; Plant Extracts - isolation & purification; Plant Extracts - therapeutic use; Polyphenols; Signaling pathway; Therapeutic applications; TLR4 protein; Toll-like receptors; Phytoestrogens; CINC; MIP-2; ICAM-1; AP-1; MPO; MyD88; TRAM; NF-κB; IFN-γ; PI3K; ERK5; Ang-2; Ang-1; iNOS; PAI-1; Immunomodulatory; ARDS; p38MAPK; PPAR-γ; TGFBBR; Acute lung injury; sTNFr; VWF; HGF; IL-4; IL-13; IL-1β; IL-8; IL-10; IL-6; TIRAP; IL-18; TRIF; Anti-inflammatory; MMP-9; TLR4; TLR2; NO; IL-1Ra; COX-2; HO-1; LPS; Nrf2/HO-1; HDL; Signaling pathway; TAK1; Nrf2; MD-2; TGF-β; VEGF; BALF; AKT; KGF; RAGE; GR-α; GR-β; STAT; DES; TNF-α; ALI
• ISSN: 1567-5769; 1878-1705
• DOI: 10.1016/j.intimp.2021.108204

•This paper highlights the various therapeutic potentials of isoflavones.•The role of isoflavones against lung injury has been surveyed.•Isoflavones showed protection against ALI via various mechanisms of action.•Isoflavones exert a protective role in alleviating the symptoms of ALI. Acute lung injury (ALI) is a life-threatening syndrome that possibly leads to high morbidity and mortality as no therapy exists. Several natural ingredients with negligible adverse effects have recently been investigated to possibly inhibit the inflammatory pathways associated with ALI at the molecular level. Isoflavones, as phytoestrogenic compounds, are naturally occurring bioactive compounds that represent the most abundant category of plant polyphenols (Leguminosae family). A broad range of therapeutic activities of isoflavones, including antioxidants, chemopreventive, anti-inflammatory, antiallergic and antibacterial potentials, have been extensively documented in the literature. Our review exclusively focuses on the possible anti-inflammatory, antioxidant role of botanicals’-derived isoflavones against ALI and their immunomodulatory effect in experimentally induced ALI. Despite the limited scope covering their molecular mechanisms, isoflavones substantially contributed to protecting from ALI via inhibiting toll-like receptor 4 (TLR4)/Myd88/NF-κB pathway and subsequent cytokines, chemokines, and adherent proteins. Nonetheless, future research is suggested to fill the gap in elucidating the protective roles of isoflavones to alleviate ALI concerning antioxidant potentials, inhibition of the inflammatory pathways, and associated molecular mechanisms.