Comparison of different digestive tract models for estimating bioaccessibility of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) from red slag ‘Kieselrot’

• Published in: International journal of hygiene and environmental health Vol. 203; no. 3; pp. 263 - 273
• Main Authors: Wittsiepe, Jurgen, Schrey, Petra, Hack, Alfons, Selenka, Fidelis, Wilhelm, Michael
• Format: Journal Article
• Language: English
• Published: Jena Elsevier GmbH 01.03.2001; Elsevier
• Subjects: Benzofurans - pharmacokinetics; bioaccessibility; Biological and medical sciences; Biological Availability; Chemical and industrial products toxicology. Toxic occupational diseases; Dibenzofurans, Polychlorinated; Digestive System - metabolism; digestive tract model; Humans; Kieselrot (red slag); Medical sciences; Metals and various inorganic compounds; Models, Biological; Polychlorinated dibenzo-p-dioxins; Polychlorinated Dibenzodioxins - analogs & derivatives; Polychlorinated Dibenzodioxins - pharmacokinetics; Polychlorinated dibenzofurans; Soil Pollutants - pharmacokinetics; Toxicology; Polychlorinated dibenzo-p-dioxins; digestive tract model; Kieselrot (red slag); bioaccessibility; Polychlorinated dibenzofurans; Human; Toxicology; Health and environment; Digestive system; Models; Chlorine containing polymer; Comparative study
• ISSN: 1438-4639; 1618-131X
• DOI: 10.1078/S1438-4639(04)70037-1

‘Kieselrot’ (red slag), a highly PCDD/F-contaminated leaching residue from a copper production process, has been used as surface layer for more than 1.000 sports fields, playgrounds and pavements in Germany and neighbouring countries. Children can ingest this material directly by hand-to-mouth activities or soil-pica behaviour. Furthermore secondary contamination of farm land or kitchen gardens by drift of red slag dust may lead to an enrichment of PCDD/F within the food-chain. PCDD/F can be mobilized from contaminated materials by digestive juices and thus become bio-accessible for intestinal absorption. Two different digestive tract models were used to estimate the bioaccessibility of PCDD/F from red slag and to study the influence of food material on the mobilization of the contaminants. The bioaccessibility of PCDD/F from red slag depends on the charge of red slag material used, the bile content of the intestinal juice and on the presence of lipophilic foodstuffs. A low bioaccessibility of less than 5 % was found when using a digestive tract model with a low bile content and in absence of food material. The bioaccessibility was estimated to be more than 60 % when using a model with a higher bile content and in the presence of whole milk powder. A low bioaccessibility of PCDD/F from red slag in general - as assumed until now and mentioned in legal provision -was not confirmed by our study. Considering observations for the different homologue groups it is obvious that bioaccessibility is the first of several important steps to estimate human health risks arising from contaminated materials. In case red slag contaminated with PCDD/F their absorption rate in the digestive tract and/or metabolism might be at least just like important.