Identification by Comparative Genomic Hybridization of Genetic Changes Involved in Tumoral Progression of a T-Cell Non-Hodgkin Lymphoma

• Published in: Cancer genetics and cytogenetics Vol. 117; no. 1; pp. 41 - 44
• Main Authors: Arranz, Eva, Martı́nez-Delgado, Beatriz, Richart, Alberto, Osorio, Ana, Cebrián, Arancha, Robledo, Mercedes, Rivas, Carmen, Benı́tez, Javier
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.2000; Elsevier Science
• Subjects: Biological and medical sciences; Hematologic and hematopoietic diseases; Humans; Karyotyping; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, T-Cell - genetics; Lymphoma, T-Cell - pathology; Male; Medical sciences; Middle Aged; Nucleic Acid Hybridization - methods; Human; Molecular hybridization; Relapse; Pathophysiology; Copy number; Pathogenesis; Exploration; Malignant hemopathy; Non Hodgkin lymphoma; Genetic determinism; Case study; Lymphoproliferative syndrome; DNA; Tumor progression; Cytogenetics; Genetics; Complication; Molecular biology; Genome; Comparative study
• ISSN: 0165-4608; 1873-4456
• DOI: 10.1016/S0165-4608(99)00139-9

Comparative genomic hybridization (CGH) was used to detect chromosomal imbalances in tumor DNA from two relapsed samples obtained in stages II and IV of a T-cell non-Hodgkin lymphoma in order to identify genetic mechanisms involved in tumor progression of this neoplasm. With conventional cytogenetic techniques (CCT), a complex hyperdiploid karyotype was obtained in stage IV. Using CGH analysis, a normal profile was observed in stage II, whereas gains of 6p11.2, 7q11.2, 7q21→q32, 7q34, 10p13, Xp11.4, and loss of 4q33→qter chromosomal regions were detected in stage IV.