Proton and calcium pumping P-type ATPases and their regulation of plant responses to the environment

• Published in: Plant physiology (Bethesda) Vol. 187; no. 4; pp. 1856 - 1875
• Main Authors: Fuglsang, Anja T, Palmgren, Michael
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 04.12.2021
• Subjects: Adaptation, Physiological - drug effects; Calcium - metabolism; Calcium-Transporting ATPases - metabolism; Cell Membrane - metabolism; Focus Issue on Transport and Signaling; Ion Pumps - metabolism; Plant Physiological Phenomena - drug effects; Protein Transport - drug effects; Proton-Translocating ATPases - metabolism; Signal Transduction - drug effects
• ISSN: 0032-0889; 1532-2548; 1532-2548
• DOI: 10.1093/plphys/kiab330

Plant plasma membrane H+-ATPases and Ca2+-ATPases maintain low cytoplasmic concentrations of H+ and Ca2+, respectively, and are essential for plant growth and development. These low concentrations allow plasma membrane H+-ATPases to function as electrogenic voltage stats, and Ca2+-ATPases as “off” mechanisms in Ca2+-based signal transduction. Although these pumps are autoregulated by cytoplasmic concentrations of H+ and Ca2+, respectively, they are also subject to exquisite regulation in response to biotic and abiotic events in the environment. A common paradigm for both types of pumps is the presence of terminal regulatory (R) domains that function as autoinhibitors that can be neutralized by multiple means, including phosphorylation. A picture is emerging in which some of the phosphosites in these R domains appear to be highly, nearly constantly phosphorylated, whereas others seem to be subject to dynamic phosphorylation. Thus, some sites might function as major switches, whereas others might simply reduce activity. Here, we provide an overview of the relevant transport systems and discuss recent advances that address their relation to external stimuli and physiological adaptations.