Syntheses and biological evaluation of novel pseudomycin side-chain analogues. Part 2

• Published in: Bioorganic & medicinal chemistry letters Vol. 10; no. 18; pp. 2107 - 2110
• Main Authors: Chen, Shu-Hui, Sun, Xicheng, Boyer, Robert, Paschal, Jonathan, Zeckner, Doug, Current, William, Zweifel, Mark, Rodriguez, Michael
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 18.09.2000; Elsevier
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antifungal Agents - chemical synthesis; Antifungal Agents - pharmacology; Aspergillus fumigatus - drug effects; Biological and medical sciences; Candida albicans - drug effects; Cryptococcus neoformans - drug effects; Fungi - drug effects; Fungi - growth & development; Magnetic Resonance Spectroscopy; Medical sciences; Microbial Sensitivity Tests; Peptides, Cyclic - chemical synthesis; Peptides, Cyclic - chemistry; Peptides, Cyclic - pharmacology; Pharmacology. Drug treatments; Pseudomonas - chemistry; Stereoisomerism; Structure-Activity Relationship; Candida albicans; Fatty amide; Cryptococcus neoformans; Oligopeptides; Cyclic peptides; In vitro; Fungi; Antifungal agent; Chemical modification; Side chain; Hydroxyacid; Structure activity relation; Depsipeptide; Fungi Imperfecti; Aspergillus fumigatus; Chemical synthesis; Thallophyta
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/S0960-894X(00)00424-8

A series of aliphatic side-chain analogues of pseudomycin was synthesized and evaluated during the course of our side-chain SAR effort. We found that several of the pseudomycin side-chain analogues (e.g., 10) exhibited good in vitro activity against all three major fungi responsible for systemic fungal infections.