Peroxynitrite activity of hemin-functionalized reduced graphene oxide

Conducting interfaces modified with reduced graphene oxide (rGO) have shown improved electrochemical response for different analytes. The efficient formation of functionalized rGO based materials is thus of current interest for the development of sensitive and selective biosensors. Herein, we report...

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Published inAnalyst (London) Vol. 138; no. 15; pp. 4345 - 4352
Main Authors Oprea, Raluca, Peteu, Serban F, Subramanian, Palaniappan, Qi, Wang, Pichonat, Emmanuelle, Happy, Henri, Bayachou, Mekki, Boukherroub, Rabah, Szunerits, Sabine
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 07.08.2013
Subjects
Biochemistry
Conduction
Graphene
Graphite - chemistry
Hemin - chemistry
Nanocomposites
Nanomaterials
Nanostructure
Oxides
Oxides - chemistry
Peroxynitrous Acid - chemistry
Photoelectron Spectroscopy - methods
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Summary:Conducting interfaces modified with reduced graphene oxide (rGO) have shown improved electrochemical response for different analytes. The efficient formation of functionalized rGO based materials is thus of current interest for the development of sensitive and selective biosensors. Herein, we report a simple and environmentally friendly method for the formation of a hemin-functionalized rGO hybrid nanomaterial that exhibits remarkable sensitivity to peroxynitrite (ONOO(-)) in solution. The hemin-functionalized rGO hybrid nanomaterial was formed by mixing an aqueous solution of graphene oxide (GO) with hemin and sonicating the suspension for 5 h at room temperature. In addition to playing a key role in biochemical and electrocatalytic reactions, hemin has been proven to be a good reducing agent for GO. The sensitivity of the peroxynitrite sensor is ≈7.5 ± 1.5 nA mM(-1) with a detection limit of 5 ± 1.5 nM.
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ISSN:0003-2654
1364-5528
DOI:10.1039/c3an00678f