Frequent loss of heterozygosity on multiple chromosomes in Chinese esophageal squamous cell carcinomas

• Published in: Cancer letters Vol. 170; no. 2; pp. 131 - 138
• Main Authors: Ko, Josephine Mun Yee, Wong, Christina Pui Sze, Tang, Cecilia Man Ching, Lau, Kwok Wai, Lung, Maria Li
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 20.09.2001; Elsevier
• Subjects: Aged; Asian Continental Ancestry Group; Biological and medical sciences; Carcinoma, Squamous Cell - genetics; China; Chinese; Chromosome Mapping; Chromosomes; Esophageal cancer; Esophageal Neoplasms - genetics; Esophagus; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Loss of Heterozygosity; Male; Medical sciences; Middle Aged; Polymerase Chain Reaction; Tumor suppressor genes; Tumors; Asia; China; Tumor suppressor genes; Chinese; Esophageal cancer; Loss of heterozygosity; Human; Squamous cell carcinoma; Tumoral tissue; Esophageal disease; Biological marker; Chromosome; Malignant tumor; In vitro; Esophagus; Allele; Microsatellite DNA; Digestive diseases; Tumor suppressor gene
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/S0304-3835(01)00577-8

Analysis of the loss of heterozygosity (LOH) detected by polymerase chain reaction techniques using 18 polymorphic markers localized to chromosomes 3p, 5, 17, and 18q in 40 Hong Kong Chinese esophageal squamous cell carcinoma (ESC) patients showed that multiple alterations on several chromosomes are involved in ESC development. The LOH rates detected for markers on chromosome 3 ranged from 44.0 to 85.7%, for chromosome 5 from 40.9 to 61.9%, for chromosome 17 from 40.0 to 100%, and for chromosome 18 from 38.9 to 58.3%. No significant association was observed between LOH and the clinical and histopathological parameters.