N-Acetylcysteine inhibit the translocation of mixed lineage kinase-3 from cytosol to plasma membrane during transient brain ischemia in rat hippocampus

• Published in: Neuroscience letters Vol. 391; no. 1; pp. 38 - 42
• Main Authors: Pei, Dong-Sheng, Guan, Qiu-Hua, Sun, Ya-Feng, Zhang, Qing-Xiu, Xu, Tian-Le, Zhang, Guang-Yi
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 31.12.2005; Elsevier
• Subjects: Acetylcysteine - administration & dosage; Animals; Biological and medical sciences; Brain Ischemia - metabolism; Cell Membrane - drug effects; Cell Membrane - metabolism; Cerebral ischemia; Cytosol - drug effects; Cytosol - metabolism; Dose-Response Relationship, Drug; Fundamental and applied biological sciences. Psychology; Hippocampus - drug effects; Hippocampus - metabolism; Male; MAP Kinase Kinase Kinases - metabolism; Medical sciences; Mitogen-Activated Protein Kinase Kinase Kinase 11; Mixed lineage kinase-3 (MLK3); N-Acetylcysteine (NAC); Neurology; Postsynaptic density protein 95 (PSD-95); Protein Transport - drug effects; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species - metabolism; Vascular diseases and vascular malformations of the nervous system; Vertebrates: nervous system and sense organs; Cerebral ischemia; N-Acetylcysteine (NAC); Mixed lineage kinase-3 (MLK3); Postsynaptic density protein 95 (PSD-95); Rat; Enzyme; Transferases; Rodentia; Central nervous system; Acetylcysteine; Cardiovascular disease; Cytosol; Protein; Encephalon; Vertebrata; Mammalia; Ischemia; Kinase; Animal; Plasma membrane; Postsynaptic density; Hippocampus

Mixed lineage kinase-3 (MLK3) is a recently described member of the MLK subfamily of Ser/Thr protein kinases that interacts with mitogen-activated protein kinase (MAPK) pathways. In this study, we investigated the translocation of MLK3 during transient cerebral ischemia in rat hippocampus. Transient...