Continued neurogenesis is not a pre-requisite for regeneration of a topographic retino-tectal projection

• Published in: Vision research (Oxford) Vol. 41; no. 14; pp. 1765 - 1770
• Main Authors: Beaver, R.S, Dunlop, S.A, Harman, A.M, Stirling, R.V, Easter, S.S, Roberts, J.D, Beazley, L.D
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.06.2001; Elsevier Science
• Subjects: Aging - physiology; Amphibia; Animals; Autoradiography; Axotomy; Biological and medical sciences; Cell Division - physiology; Cell generation; Cilia - physiology; Electrophysiology; Eye and associated structures. Visual pathways and centers. Vision; Fundamental and applied biological sciences. Psychology; Nerve Regeneration - physiology; Optic nerve; Optic Nerve - cytology; Optic Nerve - physiology; Regeneration; Retinotopy; Vertebrates: nervous system and sense organs; Xenopus laevis; Amphibia; Regeneration; Retinotopy; Cell generation; Optic nerve; Xenopus laevis; Central nervous system; Projection; Retina; Optic tectum; Salientia; Eye; Visual system; Vertebrata; Visual pathway; Brain (vertebrata)
• ISSN: 0042-6989; 1878-5646
• DOI: 10.1016/S0042-6989(01)00053-0

Electrophysiological recording demonstrated that visuo-tectal projections are topographically organised after optic nerve regeneration in aged Xenopus laevis. 3H-thymidine autoradiography confirmed previous reports [Taylor, Lack, & Easter, Eur. Journal of Neuroscience 1 (1989) 626–638] that cell division had already ceased at the retinal ciliary margin. The results demonstrate that, contrary to a previous suggestion [Holder & Clarke, Trends in Neuroscience 11 (1988) 94–99], continued neurogenesis is not a pre-requisite for the re-establishment of appropriate connections with target cells.