An antimalarial stilbene from Artocarpus integer
Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl- E-but-1-enyl)-3,5,2′,4′- tetrahydroxystilbene with an EC 50 of 1.7 μg/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4-isopentenyl...
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| Published in | Phytochemistry (Oxford) Vol. 54; no. 4; pp. 415 - 417 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
OXFORD
Elsevier Ltd
01.06.2000
Elsevier |
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| Online Access | Get full text |
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| Abstract | Antimalarial activity-guided study of the aerial parts of
Artocarpus integer led to the isolation of the prenylated stilbene,
trans-4-(3-methyl-
E-but-1-enyl)-3,5,2′,4′- tetrahydroxystilbene with an EC
50 of 1.7 μg/ml against
Plasmodium falciparum in culture. The known stilbenes,
trans-4-isopentenyl-3,5,2′,4′-tetrahydroxystilbene and 4-methoxy-2,2-dimethyl-6-(2-(2,4-dihydroxy)phenyl-
trans-ethenyl)chromene, were also isolated. Structures of these compounds were deduced on the basis of their spectral data. |
|---|---|
| AbstractList | Antimalarial activity-guided study of the aerial parts of
Artocarpus integer led to the isolation of the prenylated stilbene,
trans-4-(3-methyl-
E-but-1-enyl)-3,5,2′,4′- tetrahydroxystilbene with an EC
50 of 1.7 μg/ml against
Plasmodium falciparum in culture. The known stilbenes,
trans-4-isopentenyl-3,5,2′,4′-tetrahydroxystilbene and 4-methoxy-2,2-dimethyl-6-(2-(2,4-dihydroxy)phenyl-
trans-ethenyl)chromene, were also isolated. Structures of these compounds were deduced on the basis of their spectral data. Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl-E-but-1-enyl)-3,5,2',4'-tetrahydroxystilbene with an EC50 of 1.7 micrograms/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4-isopentenyl-3,5,2',4'-tetrahydroxystilbene and 4-methoxy-2,2-dimethyl-6-(2-(2,4-dihydroxy)phenyl-trans-ethenyl)chromene , were also isolated. Structures of these compounds were deduced on the basis of their spectral data. Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl-E-but-1-enyl)-3,5,2',4'-tetrahydroxystilbene with an EC50 of 1.7 mu g/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4-isopentenyl-3,5,2',4'-tetrahydroxystilbene and 4-methoxy-2,2-dimethyl-6-(2-(2,4-dihydroxy)phenyl-trans-ethenyl)chromene, were also isolated. Structures of these compounds were deduced on the basis of their spectral data. (C) 2000 Elsevier Science Ltd. All rights reserved. |
| Author | Oonanant, Worrapoj Tanticharoen, Morakot Thebtaranonth, Yodhathai Kittakoop, Prasat Boonlaksiri, Choosak Kongsaeree, Palangpon |
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| Cites_doi | 10.3109/08820139809022712 10.1016/S0031-9422(97)00143-X 10.1126/science.781840 10.1248/yakushi1947.107.11_914 10.1128/AAC.16.6.710 10.1246/cl.1978.1241 |
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| Keywords | Jumpada Plasmodium falciparum Antimalarial activity Moraceae 3,5,2′,4′-Tetrahydroxystilbene Artocarpus integer LECTIN 3,5,2 ',4 '-tetrahydroxystilbene PROLIFERATION antimalarial activity Antimalarial Molecular structure Pharmacognosy Biological activity Stilbene derivatives Medicinal plant Folk medicine Dicotyledones Angiospermae Parasiticid Plant origin Isolation Above ground plant part Spermatophyta |
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| Snippet | Antimalarial activity-guided study of the aerial parts of
Artocarpus integer led to the isolation of the prenylated stilbene,
trans-4-(3-methyl-... Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene,... |
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| SubjectTerms | 3,5,2′,4′-Tetrahydroxystilbene Animals Antimalarial activity Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology Artocarpus integer Biochemistry & Molecular Biology Biological and medical sciences Chemical constitution Fundamental and applied biological sciences. Psychology General pharmacology Jumpada Life Sciences & Biomedicine Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Moraceae Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant physiology and development Plant Sciences Plants, Medicinal - chemistry Plasmodium falciparum Plasmodium falciparum - drug effects Science & Technology Spectrometry, Mass, Electrospray Ionization Stilbenes - isolation & purification |
| Title | An antimalarial stilbene from Artocarpus integer |
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