An antimalarial stilbene from Artocarpus integer

• Published in: Phytochemistry (Oxford) Vol. 54; no. 4; pp. 415 - 417
• Main Authors: Boonlaksiri, Choosak, Oonanant, Worrapoj, Kongsaeree, Palangpon, Kittakoop, Prasat, Tanticharoen, Morakot, Thebtaranonth, Yodhathai
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.06.2000; Elsevier
• Subjects: 3,5,2′,4′-Tetrahydroxystilbene; Animals; Antimalarial activity; Antimalarials - chemistry; Antimalarials - isolation & purification; Antimalarials - pharmacology; Artocarpus integer; Biochemistry & Molecular Biology; Biological and medical sciences; Chemical constitution; Fundamental and applied biological sciences. Psychology; General pharmacology; Jumpada; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Medical sciences; Molecular Structure; Moraceae; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant physiology and development; Plant Sciences; Plants, Medicinal - chemistry; Plasmodium falciparum; Plasmodium falciparum - drug effects; Science & Technology; Spectrometry, Mass, Electrospray Ionization; Stilbenes - isolation & purification; Thailand; Asia; South east Asia; Jumpada; Plasmodium falciparum; Antimalarial activity; Moraceae; 3,5,2′,4′-Tetrahydroxystilbene; Artocarpus integer; LECTIN; 3,5,2 ',4 '-tetrahydroxystilbene; PROLIFERATION; antimalarial activity; Antimalarial; Molecular structure; Pharmacognosy; Biological activity; Stilbene derivatives; Medicinal plant; Folk medicine; Dicotyledones; Angiospermae; Parasiticid; Plant origin; Isolation; Above ground plant part; Spermatophyta
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(00)00074-1

Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl- E-but-1-enyl)-3,5,2′,4′- tetrahydroxystilbene with an EC 50 of 1.7 μg/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4-isopentenyl-3,5,2′,4′-tetrahydroxystilbene and 4-methoxy-2,2-dimethyl-6-(2-(2,4-dihydroxy)phenyl- trans-ethenyl)chromene, were also isolated. Structures of these compounds were deduced on the basis of their spectral data.