Reactive oxygen species- and nitric oxide-dependent regulation of ion and metal homeostasis in plants

• Published in: Journal of experimental botany Vol. 74; no. 19; pp. 5970 - 5988
• Main Authors: Sandalio, Luisa M, Espinosa, Jesús, Shabala, Sergey, León, José, Romero-Puertas, María C
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 13.10.2023
• Subjects: Review Papers; signaling; transporters; transcriptional regulation; post-translational regulation; reactive oxygen species; reactive nitrogen species; Heavy metals; ion channels; nutrients
• ISSN: 0022-0957; 1460-2431
• DOI: 10.1093/jxb/erad349

Abstract Deterioration and impoverishment of soil, caused by environmental pollution and climate change, result in reduced crop productivity. To adapt to hostile soils, plants have developed a complex network of factors involved in stress sensing, signal transduction, and adaptive responses. The chemical properties of reactive oxygen species (ROS) and reactive nitrogen species (RNS) allow them to participate in integrating the perception of external signals by fine-tuning protein redox regulation and signal transduction, triggering specific gene expression. Here, we update and summarize progress in understanding the mechanistic basis of ROS and RNS production at the subcellular level in plants and their role in the regulation of ion channels/transporters at both transcriptional and post-translational levels. We have also carried out an in silico analysis of different redox-dependent modifications of ion channels/transporters and identified cysteine and tyrosine targets of nitric oxide in metal transporters. Further, we summarize possible ROS- and RNS-dependent sensors involved in metal stress sensing, such as kinases and phosphatases, as well as some ROS/RNS-regulated transcription factors that could be involved in metal homeostasis. Understanding ROS- and RNS-dependent signaling events is crucial to designing new strategies to fortify crops and improve plant tolerance of nutritional imbalance and metal toxicity. ROS and RNS are involved in nutrient and heavy metal stress sensing, signaling, and adaptive responses. They act as important hubs in the regulation of expression levels and functionality of ion channels/transporters.