Euphane- and 19(10 → 9)abeo-euphane-type triterpenoids from Jatropha gossypiifolia

Four new tetracyclic triterpenoids (1–4) were isolated from the leaves and twigs of Jatropha gossypiifolia. Their structures were elucidated by MS and NMR data analysis, together with the Mo2(OAc)4-induced CD data. Jagabeoeuphols A-C (1–3) are rare 19(10 → 9)abeo-euphane-type triterpenoids possessin...

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Published inFitoterapia Vol. 143; pp. 104582 - 5
Main Authors Luo, Si-Yuan, Pu, Rong, Tang, Ya-Qi, Fan, Run-Zhu, Yin, Sheng, Tang, Gui-Hua
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2020
Elsevier Science Ltd
Subjects
19(10 → 9)abeo-Euphane triterpenoids
Animals
Anti-inflammatory activity
China
Data analysis
Euphorbiaceae
Jatropha - chemistry
Jatropha gossypiifolia
Lipopolysaccharides
Mice
Molecular Structure
Nitric oxide
Nitric Oxide - metabolism
NMR
Nuclear magnetic resonance
Phytochemicals - isolation & purification
Phytochemicals - pharmacology
Plant Leaves - chemistry
RAW 264.7 Cells
Triterpenes - chemistry
Triterpenes - pharmacology
Triterpenoids
China
Jatropha gossypiifolia
Euphorbiaceae
Anti-inflammatory activity
19(10 → 9)abeo-Euphane triterpenoids
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Summary:Four new tetracyclic triterpenoids (1–4) were isolated from the leaves and twigs of Jatropha gossypiifolia. Their structures were elucidated by MS and NMR data analysis, together with the Mo2(OAc)4-induced CD data. Jagabeoeuphols A-C (1–3) are rare 19(10 → 9)abeo-euphane-type triterpenoids possessing a Δ5(10) group and a 7,8-epoxide moiety, and jagoseuphone A (4) is a typical euphane-type triterpenoid. The inhibitory effects of 1–4 on nitric oxide production induced by lipopolysaccharide in RAW264.7 cells were evaluated, and 4 exhibited moderate inhibitory activity with an IC50 value of 20.1 μM. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2020.104582