Short arm of chromosome 11 and sporadic Alzheimer's disease: Catalase and cathepsin D gene polymorphisms

• Published in: Neuroscience letters Vol. 432; no. 3; pp. 237 - 242
• Main Authors: Capurso, Cristiano, Solfrizzi, Vincenzo, D’Introno, Alessia, Colacicco, Anna M., Capurso, Sabrina A., Bifaro, Luigia, Menga, Roberta, Santamato, Andrea, Seripa, Davide, Pilotto, Alberto, Capurso, Antonio, Panza, Francesco
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 27.02.2008; Elsevier
• Subjects: Age of Onset; Aged; Alzheimer Disease - genetics; Alzheimer's disease; Apolipoprotein E; Apolipoproteins E - genetics; Biological and medical sciences; Case-Control Studies; Catalase - genetics; Catalase −262 C/T promoter gene polymorphism; Cathepsin D - genetics; Cathepsin D exon 2 gene polymorphism; Chromosomes, Human, Pair 11 - genetics; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia; Female; Fundamental and applied biological sciences. Psychology; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Italy; Male; Medical sciences; Middle Aged; Neurology; Polymorphism, Genetic; Vertebrates: nervous system and sense organs; Italy; Catalase −262 C/T promoter gene polymorphism; Cathepsin D exon 2 gene polymorphism; Apolipoprotein E; Alzheimer's disease; Dementia; Nervous system diseases; Enzyme; Alzheimer disease; Transcription promoter; Cerebral disorder; Peptidases; Peroxidases; Catalase; Central nervous system disease; Hydrolases; Aspartic endopeptidases; Degenerative disease; Cathepsin D; Catalase -262 C/T promoter gene polymorphism; Oxidoreductases; Polymorphism
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2007.12.026

Catalase (CAT) −262 C/T promoter (rs1001179), cathepsin D (CTSD) exon 2 (rs17571), and apolipoprotein E (APOE) gene polymorphisms were studied in 242 patients with sporadic Alzheimer's disease (AD) and 421 unrelated age-, sex-, and ethnically matched control subjects from Apulia (Southern Italy). No statistically significant differences in CAT rs1001179 and CTSD rs17571 genotype and allele distribution between AD cases and healthy controls were observed for the whole AD sample, and when AD group was categorized by age at onset in early- and late-onset AD subsets. Furthermore, we did not find any statistically significant differences in rates between CAT rs1001179 and CTSD rs17571 genotypes and AD controlling for APOE e4 allele status. Our data, at present, do not support a role of two gene polymorphisms of the short arm of the chromosome 11, the CAT rs1001179 and CTSD rs17571, as a possible susceptibility factors for sporadic AD.