Antiinflammatory agents: new series of N-substituted amino acids with complex pyrimidine structures endowed with antiphlogistic activity
A series of N-methyl- N-pyrimidin-2-yl glycines 2a–e, having the pyrimidine ring fused with a cyclohexane [ N-methyl- N-(5,6,7,8-tetrahydroquinazolin-2-yl)glycine], cyclohexene [ N-methyl- N-(5,6-dihydroquinazolin-2-yl)glycine], 1,2,3,4-tetrahydronaphthalene [ N-methyl- N-(5,6-dihydrobenzo[e]quinazo...
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Published in | Farmaco (Società chimica italiana : 1989) Vol. 54; no. 1; pp. 95 - 100 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
LAUSANNE
Elsevier SAS
1999
Elsevier Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | A series of
N-methyl-
N-pyrimidin-2-yl glycines
2a–e, having the pyrimidine ring fused with a cyclohexane [
N-methyl-
N-(5,6,7,8-tetrahydroquinazolin-2-yl)glycine], cyclohexene [
N-methyl-
N-(5,6-dihydroquinazolin-2-yl)glycine], 1,2,3,4-tetrahydronaphthalene [
N-methyl-
N-(5,6-dihydrobenzo[e]quinazolin-2-yl)glycine], benzopyrane [
N-methyl-
N-(5-phenyl-5
H-[1]benzopyrano[4,3-
d]pyrimidin-2-yl)glycine] and benzothiopyrane [
N-methyl-
N-(5
H-[1]benzothiopyrano[4,3-
d]pyrimidin-2-yl)glycine] ring, was prepared and tested for antiinflammatory activity. With the same purpose a number of
N-5
H-[1]benzopyrano[4,3-
d]pyrimidin-2-yl substituted amino acids
3a–e, having a different chain length and branching were also synthesized and tested. All the described products
2 and
3 showed an appreciable antiphlogistic activity, particularly
2b and
2c. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0014-827X 1879-0569 |
DOI: | 10.1016/S0014-827X(98)00109-8 |