Efficient resolution of racemic 1,1′-bi-2-naphthol with chiral selectors identified from a small library

• Published in: Journal of Chromatography A Vol. 1062; no. 1; pp. 87 - 93
• Main Authors: Huang, Junmin, Li, Tingyu
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 07.01.2005; Elsevier
• Subjects: 1,1′-Bi-2-naphthol; Analytical chemistry; Chemistry; Chromatographic methods and physical methods associated with chromatography; Chromatography, High Pressure Liquid; Combinatorial library; Enantiomer separation; Exact sciences and technology; Naphthols - isolation & purification; Other chromatographic methods; Stereoisomerism; 1,1′-Bi-2-naphthol; Combinatorial library; Enantiomer separation; Separation; Peptides; Combinatorial chemistry; HPLC chromatography; Chiral stationary phase; Chiral selector; Optical resolution; Chemical compound library; Enantiomer; 1,1'-Bi-2-naphthol; Phenols; Naphthol derivatives
• ISSN: 0021-9673
• DOI: 10.1016/j.chroma.2004.11.016

Efficient resolution of racemic 1,1′-bi-2-naphthol, a well-studied analyte in chiral separation, was achieved using selectors developed from a small library. Separation factors (up to 7.2) obtained are significantly higher than the ones reported previously for this analyte. The library consists of 121 members and it does not contain the pi deficient 3,5-dinitrobenzoyl (Dnb) group. These highly efficient stationary phases may lead to the practical large-scale chromatographic resolution of enantiomers of 1,1′-bi-2-naphthol, which are widely used as chiral auxiliaries and ligands in asymmetric synthesis.