Pleiotropic Effect of Lipoprotein-Apheresis on the Soluble Form of Activated Leukocyte Cell Adhesion Molecule (sALCAM) in Familial Hypercholesterolaemia

Atherosclerosis is an inflammatory disorder in which several converging immune responses modulate and induce lipid accumulation in macrophages. Activated leukocyte cell adhesion molecule (ALCAM) has been described as a structural homologue of HDL-receptor and functions as a pattern recognition recep...

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Published inExperimental and clinical endocrinology & diabetes Vol. 127; no. 5; p. 276
Main Authors von Bauer, Rüdiger, Oikonomou, Dimitrios, Sulaj, Alba, Kopf, Stefan, Fleming, Thomas, Rudofsky, Gottfried, Nawroth, Peter
Format Journal Article
LanguageEnglish
Published Germany 01.05.2019
Subjects
Adult
Aged
Antigens, CD - blood
Atherosclerosis - blood
Atherosclerosis - therapy
Blood Component Removal - methods
Cell Adhesion Molecules, Neuronal - blood
Cholesterol, LDL - blood
Female
Fetal Proteins - blood
Humans
Hypercholesterolemia - blood
Hypercholesterolemia - genetics
Hypercholesterolemia - therapy
Inflammation - blood
Lipoprotein(a) - blood
Male
Middle Aged
Receptors, Pattern Recognition - blood
Treatment Outcome
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Summary:Atherosclerosis is an inflammatory disorder in which several converging immune responses modulate and induce lipid accumulation in macrophages. Activated leukocyte cell adhesion molecule (ALCAM) has been described as a structural homologue of HDL-receptor and functions as a pattern recognition receptor (PRR), while its soluble form sALCAM is involved in ALCAM-dependent and -independent immune mechanisms. The aim of this study was to investigate the effect of aggressive removal of low density lipoprotein-cholesterol (LDL-C) and lipoprotein(a) (Lp [a]) by lipoprotein-apheresis (LA) on sALCAM and blood viscosity as well as to evaluate its association with lipoproteins and serum markers of inflammation.
ISSN:1439-3646
DOI:10.1055/a-0630-0232