Near-field Raman spectroscopy of biological nanomaterials by in situ laser-induced synthesis of tip-enhanced Raman spectroscopy tips

We report a new approach in tip-enhanced Raman spectroscopy (TERS) in which TERS-active tips with enhancement factors of ∼10(-5)× can be rapidly (1-3 min) produced in situ by laser-induced synthesis of silver nanoparticles at the tip apex. The technique minimizes the risks of tip contamination and d...

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Bibliographic Details
Published inOptics letters Vol. 37; no. 12; p. 2256
Main Authors Sinjab, Faris, Lekprasert, Banyat, Woolley, Richard A J, Roberts, Clive J, Tendler, Saul J B, Notingher, Ioan
Format Journal Article
LanguageEnglish
Published United States 15.06.2012
Subjects
Lasers
Metal Nanoparticles - chemistry
Microscopy, Atomic Force
Nanotechnology - methods
Nanotubes, Peptide - chemistry
Phenylalanine - analogs & derivatives
Phenylalanine - chemistry
Silver - chemistry
Spectrum Analysis, Raman - methods
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Summary:We report a new approach in tip-enhanced Raman spectroscopy (TERS) in which TERS-active tips with enhancement factors of ∼10(-5)× can be rapidly (1-3 min) produced in situ by laser-induced synthesis of silver nanoparticles at the tip apex. The technique minimizes the risks of tip contamination and damage during handling and provides in situ feedback control, which allows the prediction of the tip performance. We show that TERS tips produced by this technique enable the measurement of spatially resolved TERS spectra of self-assembled peptide nanotubes with a spatial resolution of ∼20  nm.
ISSN:1539-4794
DOI:10.1364/ol.37.002256