Hypoxia inducible factor-1 expression mediates myocardial response to ischemia late after acute myocardial infarction

• Published in: International journal of cardiology Vol. 99; no. 2; pp. 337 - 339
• Main Authors: Parisi, Quintino, Biondi-Zoccai, Giuseppe G.L., Abbate, Antonio, Santini, Daniele, Vasaturo, Fortunata, Scarpa, Susanna, Bussani, Rossana, Leone, Antonio Maria, Petrolini, Alessandro, Silvestri, Furio, Biasucci, Luigi M., Baldi, Alfonso
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 18.03.2005; Elsevier Science
• Subjects: Acute myocardial infarction; Aged; Animals; Biological and medical sciences; Cadaver; Cardiology. Vascular system; Coronary heart disease; Disease Models, Animal; DNA-Binding Proteins - biosynthesis; Female; Gene Expression - physiology; Heart; Humans; Hypoxia inducible factor-1 expression; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemia; Male; Medical sciences; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Myocarditis. Cardiomyopathies; Myocardium - metabolism; Myocardium - pathology; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Nuclear Proteins - biosynthesis; Rats; Rats, Sprague-Dawley; Time Factors; Transcription Factors - biosynthesis; Ischemia; Acute myocardial infarction; Hypoxia inducible factor-1 expression; Myocardial infarction; Late; Acute; Cardiovascular disease; Myocardial ischemia; Gene expression; Coronary heart disease; Myocardial disease; Vascular disease; Response; Transcription factor HIF1
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2003.11.038

We report hypoxia-inducible factor-1 (HIF-1) expression in myocardium of patients with recent acute myocardial infarction (AMI), supporting the hypothesis of HIF-1 as a possible mediator of response to ischemia. A potential diagnostic role of determining tissue expression of HIF-1 as a marker of ischemia, and potential therapeutic implications by trying to modulate HIF-1 activity in order to promote beneficial effects of HIF-1 related genes (e.g. expression of vascular endothelial growth factor (VEGF)) may derive.