Perceived parenting pattern and response to antidepressants in patients with major depression

• Published in: Journal of affective disorders Vol. 52; no. 1; pp. 59 - 66
• Main Authors: Sakado, Kaoru, Sato, Tetsuya, Uehara, Toru, Sakado, Miwako, Someya, Toshiyuki
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 1999; Elsevier
• Subjects: Adult; Amitriptyline - therapeutic use; Antidepressive Agents, Second-Generation - therapeutic use; Antidepressive Agents, Tricyclic - therapeutic use; Attitude; Biological and medical sciences; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - psychology; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Imipramine - therapeutic use; Major depression; Male; Maprotiline - therapeutic use; Medical sciences; Middle Aged; Neuropharmacology; Object Attachment; Parent-Child Relations; Parental bonding instrument; Parenting; Personality; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Retrospective Studies; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome; Treatment outcome; Parental bonding instrument; Personality; Major depression; Mood disorder; Human; Chemotherapy; Treatment; Social interaction; Psychotropic; Risk factor; Antidepressant agent; Depression; Evolution; Infantile experience; Parent child relation
• ISSN: 0165-0327; 1573-2517
• DOI: 10.1016/S0165-0327(98)00062-7

Background: No systematic study has been conducted to explore the relationship of dysfunctional parenting early in life, as measured by the Parental Bonding Instrument (PBI), to outcomes of depression, although a number of studies have related parenting behaviors to the development of depression in adulthood. Methods: The relationship between PBI scores and 4-month outcomes after treatment with antidepressants was explored in 60 outpatients with major depression, controlling for potentially confounding factors. Results: A multiple logistic regression analysis suggested that low levels of paternal care, unmarried condition, non-melancholic features, and a high isolation tendency were all factors that contributed to poor outcomes for depression. The predictive power of low paternal care was not influenced by levels of depression or neuroticism. Limitation: This study did not attempt to explore whether the effects of parenting of father and mother on outcomes for depression may differ between male and female subjects. Conclusion: The results suggest that low levels of paternal care may be an independent predictor of a poor response to treatment with adequate antidepressants.