Association between ADRB2, IL33, and IL2RB gene polymorphisms and lung cancer risk in a Chinese Han population

• Published in: International immunopharmacology Vol. 77; p. 105930
• Main Authors: Mei, Lijun, Huang, Chongya, Wang, Ajing, Zhang, Xian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2019; Elsevier BV
• Subjects: ADRB2; Aged; Alleles; Asian Continental Ancestry Group - genetics; Case-Control Studies; Female; Genetic analysis; Genetic Predisposition to Disease; Genotype; Genotypes; Health risk assessment; Health risks; Humans; IL2RB; IL33; Interleukin-2 Receptor beta Subunit - genetics; Interleukin-33 - genetics; Lung cancer; Lung Neoplasms - epidemiology; Lung Neoplasms - genetics; Male; Middle Aged; Polymorphism, Single Nucleotide; Population studies; Receptors, Adrenergic, beta-2 - genetics; Risk; Single nucleotide polymorphisms (SNPs); Smoking; Subgroups; Tobacco smoke; IL33; Single nucleotide polymorphisms (SNPs); ADRB2; Lung cancer; IL2RB
• ISSN: 1567-5769; 1878-1705
• DOI: 10.1016/j.intimp.2019.105930

•Rs1042711 and rs1560642 (ADRB2 polymorphisms) are risk alleles for lung cancer.•Polymorphism in IL33 (rs7025417) is associated with decreased risk of lung cancer.•IL2RB alleles (rs5756523 and rs2284033) are protective against risk of lung cancer. This study aimed to explore the associations between polymorphisms of a very important pharmacogene, ADRB2, two inflammation-related genes, IL33 and IL2RB, and the risk of lung cancer. Six polymorphisms of ADRB2, IL33, and IL2RB were genotyped in 300 lung cancer patients and 300 healthy controls using MassARRAY. The relationship between genotypes and lung cancer risk was evaluated using chi-square tests. The minor allele of rs1042711 was a risk allele for lung cancer, whereas the minor alleles of rs7025417 and rs5756523 had protective effects against lung cancer (p＜0.05). The CT genotype of rs1042711 and the GT genotype of rs1560642 were associated with increased risk of lung cancer, whereas the CC and AA genotypes of rs7025417 and the CT and CC genotypes of rs5756523 were associated with decreased disease risk (p < 0.05). Genetic model analysis shows that rs1042711 and rs1560642 were associated with increased risk of lung cancer; whereas rs7025417, rs5756523, and rs2284033 were associated with decreased disease risk (p < 0.05). Stratification analysis showed that rs1042711 and rs1560642 were associated with increased risk of lung cancer in nonsmokers and smokers, respectively, whereas rs7025417 and rs5756523 were associated with decreased disease risk in both subgroups (p＜0.05). Our results shed new light on the association between polymorphisms of ADRB2, IL33, and IL2RB and the risk of lung cancer.