Chronic exposure to ozone and nitric acid vapor results in increased levels of rat pulmonary putrescine

• Published in: Archives of toxicology Vol. 72; no. 7; pp. 445 - 449
• Main Authors: SINDHU, R. K, MAUTZ, W. J, KIKKAWA, Y
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.06.1998
• Subjects: Air; Air Pollutants - pharmacology; Animals; Biological and medical sciences; Body Weight - drug effects; Environmental pollutants toxicology; Lung - chemistry; Lung - drug effects; Male; Medical sciences; Nitric Acid - pharmacology; Ozone - pharmacology; Putrescine - analysis; Rats; Rats, Inbred F344; Spermidine - analysis; Spermine - analysis; Toxicology; Polyamine; Rat; Respiratory disease; Toxicity; Lung; Rodentia; Ozone; Air; Putrescine; Metabolism; Toxic association; Nitric acid; Inhalation; Pollutant; Vertebrata; Chronic; Mammalia; Animal; Repair
• ISSN: 0340-5761; 1432-0738
• DOI: 10.1007/s002040050525

In the past decade, there has been growing public concern for the human health effects of exposure to environmental pollutants. Ozone (O3) is one of the most reactive components of photochemical air pollution. Despite extensive investigations by many laboratories on the functional, biochemical, and cellular effects of O3 exposure in humans, animals, and in vitro systems, questions remain concerning the potential adverse effects to human health represented by chronic near-ambient exposure to this environmental pollutant. In the present investigation, the influence of inhalation of O3 and nitric acid (HNO3) vapor on polyamine levels was examined in rat lungs. Male F344/N rats were exposed nose-only to 0.15 ppm O3 and 50 microg/m3 HNO3 vapor alone and in combination for 4 hours/day. 3 days/week for a total of 40 weeks. At this time the animals were sacrificed and their lungs were examined for polyamine contents. Exposure to O3 and O3 plus HNO3 vapor caused a significant increase in the putrescine content of the lung compared to the air-exposed controls (P < 0.05). The concentrations of pulmonary spermidine and spermine were not significantly increased by exposure to either O3 or HNO3 vapor alone or in combination compared to the air-exposed controls. The role of polyamines in repair and anti-inflammatory processes has been discussed.