Upregulation of des-gamma-carboxy-prothrombin after portal vein embolization in a cirrhotic patient with hepatocellular carcinoma

A 73-year-old female with hepatocellular carcinoma (HCC) received percutaneous transhepatic portal vein embolization (PTPE) before extensive right lobe hepatectomy. Serum levels of des-gamma-carboxy-prothrombin (DCP) were increased and remained at a high level until hepatectomy. Immunohistochemical...

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Published inClinical journal of gastroenterology Vol. 8; no. 5; pp. 330 - 334
Main Authors Sohda, Tetsuro, Iwata, Kaoru, Anan, Akira, Kunimoto, Hideo, Yotsumoto, Kaoru, Yokoyama, Keiji, Morihara, Daisuke, Takeyama, Yasuaki, Shakado, Satoshi, Osame, Akinobu, Kora, Shinichi, Ohishi, Jun, Yamauchi, Yasushi, Noritomi, Tomoaki, Yoshimitsu, Kengo, Yamashita, Yuichi, Sakisaka, Shotaro
Format Journal Article
LanguageEnglish
Published Tokyo Springer Japan 01.10.2015
Subjects
Abdominal Surgery
Aged
Biomarkers - blood
Biomarkers - metabolism
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - therapy
Case Report
Colorectal Surgery
Embolization, Therapeutic
Female
Gastroenterology
Hepatectomy
Hepatology
Humans
Immunohistochemistry
Liver - metabolism
Liver Cirrhosis
Liver Neoplasms - metabolism
Liver Neoplasms - therapy
Medicine
Medicine & Public Health
Neoplasm Invasiveness
Portal Vein
Protein Precursors - blood
Protein Precursors - metabolism
Prothrombin - metabolism
Surgical Oncology
Up-Regulation
Immunohistochemistry
Hepatocellular carcinoma
Des-gamma-carboxy-prothrombin
Percutaneous transhepatic portal vein embolization
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Summary:A 73-year-old female with hepatocellular carcinoma (HCC) received percutaneous transhepatic portal vein embolization (PTPE) before extensive right lobe hepatectomy. Serum levels of des-gamma-carboxy-prothrombin (DCP) were increased and remained at a high level until hepatectomy. Immunohistochemical examination revealed that an increased expression of DCP was demonstrated not only in HCC tissues, but also in the non-cancerous liver of the right lobe, where portal blood flow was blocked off as a result of PTPE. The serum level of DCP is known to be greatly increased in patients with HCC accompanied by portal vein invasion. We speculate that this increased DCP level is caused by both increased DCP production in HCC tissue and the surrounding non-cancerous liver, where portal flow is blocked off as a result of portal invasion by HCC.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:1865-7257
1865-7265
DOI:10.1007/s12328-015-0603-x