The Eph/ephrin system symphony of gut inflammation

The extent of gut inflammation depends largely on the gut barrier's integrity and enteric neuroimmune interactions. However, the factors and molecular mechanisms that regulate inflammation-related changes in the enteric nervous system (ENS) remain largely unexplored. Eph/ephrin signaling is cri...

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Published inPharmacological research Vol. 197; p. 106976
Main Authors Qiu, Peishan, Li, Daojiang, Xiao, Cong, Xu, Fei, Chen, Xiaoyu, Chang, Ying, Liu, Lan, Zhang, Lei, Zhao, Qiu, Chen, Yuhua
Format Journal Article
LanguageEnglish
Published Elsevier 01.11.2023
Subjects
Enteric nervous system
Enteric neuroimmune interaction
Eph/ephrin
Gut homeostasis
Gut inflammation
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Summary:The extent of gut inflammation depends largely on the gut barrier's integrity and enteric neuroimmune interactions. However, the factors and molecular mechanisms that regulate inflammation-related changes in the enteric nervous system (ENS) remain largely unexplored. Eph/ephrin signaling is critical for inflammatory response, neuronal activation, and synaptic plasticity in the brain, but its presence and function in the ENS have been largely unknown to date. This review discusses the critical role of Eph/ephrin in regulating gut homeostasis, inflammation, neuroimmune interactions, and pain pathways. Targeting the Eph/ephrin system offers innovative treatments for gut inflammation disorders, offering hope for enhanced patient prognosis, pain management, and overall quality of life.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2023.106976