Chimeric vaccine strain of type O foot-and-mouth disease elicits a strong immune response in pigs against ME-SA and SEA topotypes

• Published in: Veterinary microbiology Vol. 229; pp. 124 - 129
• Main Authors: Ko, Mi-Kyeong, Jo, Hye-Eun, Choi, Joo-Hyung, You, Su-Hwa, Shin, Sung Ho, Jo, Hyundong, Lee, Min-Ja, Kim, Su-Mi, Kim, Byounghan, Park, Jong-Hyeon
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2019; Elsevier BV
• Subjects: Broad spectrum; Epidemics; Foot & mouth disease; Foot-and-mouth disease; Immune response; Immunogenicity; Infectious diseases; Neutralizing; Pigs; Strains (organisms); Swine; Vaccine; Vaccine development; Vaccines; Viruses; VP1 protein; VP3 protein; Pigs; Broad spectrum; Foot-and-mouth disease; Vaccine
• ISSN: 0378-1135; 1873-2542
• DOI: 10.1016/j.vetmic.2018.12.023

•We obtained a vaccine virus with improved stability and a broad antigen spectrum.•The virus could be differentiated from wild-type strains by a rapid diagnosis kit.•The immunized pigs had a high level of neutralizing antibodies against four O topotypes.•The antibodies in the pigs against FMDV were present during the experimental period. Foot-and-mouth disease (FMD) is an acute infectious disease occurring in cloven-hoofed animals. There are many variations of the virus, making it difficult to protect against the various strains with one virus vaccine. The immunogenicity has generally been evaluated in pigs using neutralizing antibodies to determine the protection level against foot-and-mouth disease virus type O. Therefore, the vaccine from the chimeric vaccine strain of ME-SA (VP4, VP2, and VP3) and SEA (VP1) topotypes developed in this study is expected to be able to protect with high neutralizing antibody titers against most of the eight FMD viruses of the four different topotypes (ME-SA, SEA, Cathay, and EURO-SA) of type O in pigs. This is a new technique for powerful vaccine development, with multiple preventive roles against various epidemic FMD strains.