Cytotoxic and anti-inflammatory constituents from Momordica cochinchinensis seeds

• Published in: Fitoterapia Vol. 139; p. 104360
• Main Authors: Wang, Mengyue, Zhan, Zhibin, Xiong, Ying, Zhang, Ying, Li, Xiaobo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2019; Elsevier Science Ltd
• Subjects: Animals; Anti-inflammation; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Cell Line, Tumor; China; Cytotoxicity; Gac; Humans; Inflammation; Lignan; Lignans; Lignans - isolation & purification; Lignans - pharmacology; Lipopolysaccharides; Mice; Molecular Structure; Momordica - chemistry; Momordica cochinchinensis; Nitric Oxide - metabolism; NMR; Nuclear magnetic resonance; Phytochemicals - isolation & purification; Phytochemicals - pharmacology; RAW 264.7 Cells; Saponins; Saponins - isolation & purification; Saponins - pharmacology; Seeds; Seeds - chemistry; Toxicity; Tumor cells; Tumor necrosis factor-α; Tumors; China; Gac; Lignan; Cytotoxicity; Momordica cochinchinensis; Anti-inflammation
• ISSN: 0367-326X; 1873-6971
• DOI: 10.1016/j.fitote.2019.104360

Five new lignans mubiesins A − E (1–5), together with twenty-seven known compounds (6–32), were isolated from the cytotoxicity and anti-inflammation portions of Momordica cochinchinensis seeds which were widely used for various tumors and inflammations. Their structures were elucidated by extensive spectroscopic analyses (HR-MS, UV, CD, IR, 1D-NMR, and 2D-NMR). Their cytotoxic and anti-inflammatory activities were evaluated in vitro. Various lignans and saponins showed the significant activities, they could obviously inhibit the growth of tumor cells and the release of NO and TNF-α in RAW 264.7 cells induced by LPS. [Display omitted]