Evidence for mendelian inheritance in the pathogenesis of lung cancer

Segregation analyses that allowed for variable age of onset of lung cancer and smoking history were performed on 337 families, each ascertained through a lung cancer proband. Results indicated compatibility of the data with mendelian codominant inheritance of a rare major autosomal gene that produce...

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Bibliographic Details
Published inJNCI : Journal of the National Cancer Institute Vol. 82; no. 15; p. 1272
Main Authors Sellers, T A, Bailey-Wilson, J E, Elston, R C, Wilson, A F, Elston, G Z, Ooi, W L, Rothschild, H
Format Journal Article
LanguageEnglish
Published United States 01.08.1990
Subjects
Adult
Aged
Analysis of Variance
Chromosomes - physiology
Environment
Family Health
Female
Genes, Dominant - genetics
Genes, Recessive - genetics
Humans
Lung Neoplasms - etiology
Lung Neoplasms - genetics
Male
Middle Aged
Models, Genetic
Pedigree
Smoking
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Summary:Segregation analyses that allowed for variable age of onset of lung cancer and smoking history were performed on 337 families, each ascertained through a lung cancer proband. Results indicated compatibility of the data with mendelian codominant inheritance of a rare major autosomal gene that produces earlier age of onset of the cancer. Segregation at this putative locus could account for 69% and 47% of the cumulative incidence of lung cancer in individuals up to ages 50 and 60, respectively. The gene was involved in only 22% of all lung cancers in persons up to age 70, a reflection of an increasing proportion of noncarriers succumbing to the effects of long-term exposure to tobacco.
ISSN:0027-8874
DOI:10.1093/jnci/82.15.1272