Randomized Trial of Closed-Loop Control in Very Young Children with Type 1 Diabetes

• Published in: The New England journal of medicine Vol. 386; no. 3; pp. 209 - 219
• Main Authors: Ware, Julia, Allen, Janet M, Boughton, Charlotte K, Wilinska, Malgorzata E, Hartnell, Sara, Thankamony, Ajay, de Beaufort, Carine, Schierloh, Ulrike, Fröhlich-Reiterer, Elke, Mader, Julia K, Kapellen, Thomas M, Rami-Merhar, Birgit, Tauschmann, Martin, Nagl, Katrin, Hofer, Sabine E, Campbell, Fiona M, Yong, James, Hood, Korey K, Lawton, Julia, Roze, Stephane, Sibayan, Judy, Bocchino, Laura E, Kollman, Craig, Hovorka, Roman
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 20.01.2022
• Subjects: Adverse events; Age groups; Algorithms; Blood Glucose - analysis; Caregivers; Child; Child, Preschool; Childhood Diseases; Children; Closed loop systems; Control algorithms; Cross-Over Studies; Diabetes; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - drug therapy; Endocrinology; Endocrinology General; Equipment Design; Female; Glucose; Glycated Hemoglobin A - analysis; Glycemic Control - instrumentation; Glycemic Control - methods; Hemoglobin; Humans; Hyperglycemia - diagnosis; Hypoglycemia; Hypoglycemic Agents - administration & dosage; Infant; Insulin; Insulin - administration & dosage; Insulin Infusion Systems; Male; Pancreas; Pancreas, Artificial; Pediatrics; Pediatrics General; Sensors; Smartphones; Standard deviation; Luxembourg
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa2111673

In a multicenter, randomized, crossover trial involving children 1 to 7 years of age with type 1 diabetes, a closed-loop system was compared with sensor-augmented pump therapy in random order. The closed-loop system improved glycemic control in very young children with type 1 diabetes, without increasing the time spent in a hypoglycemic state.