Identification and antimicrobial properties of a new alkaloid produced by marine-derived Verrucosispora sp. FIM06-0036

The actinomycete strain FIM06-0036 was isolated from marine sponge sample collected from the East China Sea and identified as Verrucosispora sp. based upon the results of 16S rRNA sequence analysis. One new alkaloid, 2-ethylhexyl 1H-imidazole-4-carboxylate (1), together with a known alkaloid butyl 1...

Full description

Saved in:
Bibliographic Details
Published inNatural product research Vol. 35; no. 22; pp. 4211 - 4217
Main Authors Chen, Ming-Hong, Lian, Yun-Yang, Fang, Dong-Sheng, Chen, Li, Jia, Jia, Zhang, Wen-Long, Lin, Ru, Xie, Yang, Bi, Hong-Kai, Jiang, Hong
Format Journal Article
LanguageEnglish
Published Taylor & Francis 18.11.2021
Subjects
Actinomycete
antibiotics
antimicrobial activity
Helicobacter pylori
Verrucosispora
Online AccessGet full text

Cover

More Information
Summary:The actinomycete strain FIM06-0036 was isolated from marine sponge sample collected from the East China Sea and identified as Verrucosispora sp. based upon the results of 16S rRNA sequence analysis. One new alkaloid, 2-ethylhexyl 1H-imidazole-4-carboxylate (1), together with a known alkaloid butyl 1H-imidazole-4-carboxylate (2) was obtained from the fermentation products of this strain, the structures of compounds 1 and 2 were determined by their detailed analysis of 1 D, 2 D NMR and HR-ESI-MS data, along with literature data analysis. Compounds 1 and 2 were evaluated for their antimicrobial activity with MIC (minimum inhibitory concentration) values ranging from 8 to 256 μg · mL −1 against Helicobacter pylori, Klebsiella Pneumonia, Staphylococcus aureus and Enterococcus faecalis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1689498