Cytotoxic Natural Products Isolated from Cryptogramma crispa (L.) R. Br

Parsley fern, , is a common fern in arctic-alpine regions, and even though this species has been known since ancient times and has been presumed to cause the poisoning of horses, its natural products have not previously been investigated. Here, we characterise 15 natural products isolated from the a...

Full description

Saved in:
Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 28; no. 23; p. 7723
Main Authors Diaz, Andrea Estefania Carpinteyro, Herfindal, Lars, Andersen, Heidi Lie, Fossen, Torgils
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.11.2023
Subjects
aerial parts
Cancer
Chromatography
Cryptogramma crispa
Cytotoxicity
Ferns
Flavonoids
Flowers & plants
Leukemia
Natural products
NMR
pteroside
pterosin
Spectrum analysis
Europe
aerial parts
pterosin
NMR
Cryptogramma crispa
pteroside
cytotoxicity
Online AccessGet full text

Cover

More Information
Summary:Parsley fern, , is a common fern in arctic-alpine regions, and even though this species has been known since ancient times and has been presumed to cause the poisoning of horses, its natural products have not previously been investigated. Here, we characterise 15 natural products isolated from the aerial parts of , including the previously undescribed compound 3-malonyl pteroside D. The structure determinations were based on several advanced 1D and 2D NMR spectroscopic techniques, Circular Dichroism spectroscopy and high-resolution mass spectrometry. The pteroside derivatives exhibited selective moderate cytotoxic activity against the acute myeloid leukaemia MOLM13 cell line and no cytotoxicity against the normal heart and kidney cell lines, suggesting that their potential anticancer effect should be further investigated.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28237723