Fluorenone based fluorescent probe for selective “turn-on” detection of pyrophosphate and alanine

To sense biologically important entities with different size and dimensions, a fluorenone based fluorescent receptor was designed and synthesized. Probe 1 displayed a distinct fluorescence enhancement emission at 565nm for pyrophosphate and 530nm for alanine in polar solvent. The fluorescence titrat...

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Published inSpectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 199; pp. 465 - 471
Main Authors T, Daniel Thangadurai, I, Nithya, N, Manjubaashini, N, Bhuvanesh, G, Bharathi, R, Nandhakumar, D, Nataraj
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 15.06.2018
Subjects
Biological entities
Fluorenone
H-bonds
Stoichiometry
Zwitterionic form
H-bonds
Stoichiometry
Biological entities
Zwitterionic form
Fluorenone
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Summary:To sense biologically important entities with different size and dimensions, a fluorenone based fluorescent receptor was designed and synthesized. Probe 1 displayed a distinct fluorescence enhancement emission at 565nm for pyrophosphate and 530nm for alanine in polar solvent. The fluorescence titration experiments confirm 1:1 stoichiometric ratio with high-binding constant and very low limit of detection (LoD) values. Receptor 1 showed a highly selective and sensitive recognition to HP2O73− and to alanine over other competitive anions and amino acids. In addition, the fluorescence lifetime measurement and reversible binding study results support the practical importance of 1. [Display omitted] •A chemosensor to sense biological entities with different size and shape in polar solvent•Cost effective, strong affinity, low LOD, and reversible probe can be an effective tool in clinical trials•Alaline binds with urea moiety in zwitterionic form through four H-bonds which enhances the water solubility
ISSN:1386-1425
1873-3557
DOI:10.1016/j.saa.2017.11.013