Effects of long term administration of testosterone enanthate on glucose metabolism in rhesus monkeys

• Published in: Contraception (Stoneham) Vol. 59; no. 5; pp. 333 - 337
• Main Authors: Tyagi, Alpana, Rajalakshmi, M, Jeyaraj, D.Antony, Sharma, R.S, Bajaj, J.S
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.1999; Elsevier Science
• Subjects: Animals; Biological and medical sciences; Birth control; Blood Glucose - drug effects; Blood Glucose - metabolism; Drug Administration Schedule; Fasting; Glucose Tolerance Test; Gynecology. Andrology. Obstetrics; Hormonal contraception; insulin; Insulin - blood; Macaca mulatta; Male; Medical sciences; rhesus monkey; Testosterone - analogs & derivatives; Testosterone - blood; Testosterone - pharmacology; testosterone enanthate; Time Factors; rhesus monkey; testosterone enanthate; glucose tolerance test; insulin; Androgen; Monkey; Male; Glucose; Metabolism; Insulin; Long term; Testosterone; Vertebrata; Mammalia; Animal; Primates; Contraceptive; Carbohydrate; Sex steroid hormone
• ISSN: 0010-7824; 1879-0518
• DOI: 10.1016/S0010-7824(99)00038-4

The effects of long term administration of testosterone enanthate (TE) on glucose metabolism including glucose tolerance test (GTT) and fasting serum insulin levels were evaluated in adult rhesus monkeys kept under controlled dietary conditions. Adult male rhesus monkeys (n = 9) were administered 50 mg of TE bimonthly for 32 months, whereas control animals were injected the vehicle only. Glucose concentration reached a maximum 5 min after an intravenous glucose load and thereafter decreased gradually to reach near baseline values within 60 min. Significant changes in GTT or t 1/2 of glucose were not seen in animals treated with TE, throughout the treatment period. However, serum insulin levels decreased significantly from months 27–32 of TE treatment and returned to baseline values within 3 months of recovery.