Targeting nitric oxide to cancer cells: cytotoxicity studies of glyco- S-nitrosothiols

• Published in: Bioorganic & medicinal chemistry letters Vol. 9; no. 15; pp. 2255 - 2258
• Main Authors: Hou, Yongchun, Wang, Jianqiang, Andreana, Peter R., Cantauria, Guilleherme, Tarasia, Srikumar, Sharp, Laura, Braunschweiger, Paul G., Wang, Peng G.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 02.08.1999; Elsevier
• Subjects: Antineoplastic agents; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacology; Biological and medical sciences; Drug Screening Assays, Antitumor; Fructose - analogs & derivatives; Fructose - chemical synthesis; Fructose - pharmacology; General aspects; Glucose - analogs & derivatives; Glucose - chemical synthesis; Glucose - pharmacology; Humans; Male; Medical sciences; Nitric Oxide - metabolism; Nitric Oxide Donors - pharmacology; Nitroso Compounds - chemical synthesis; Nitroso Compounds - pharmacology; Penicillamine - analogs & derivatives; Penicillamine - pharmacology; Pharmacology. Drug treatments; Prostatic Neoplasms - pathology; Tumor Cells, Cultured; Antineoplastic agent; Human; Targeting; Aminoamide; Cytotoxicity; In vitro; Biological activity; Sulfur containing aminoacid; Cell line; Aminoglycoside; Chemical synthesis; Prostate; Tumor cell
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/S0960-894X(99)00363-7

Glyco- S-nitrosothiols, fructose-2-SNAP and glucose-2-SNAP, were synthesized and found to be much more cytotoxic than SNAP in killing DU-145 human prostate cancer cells in vitro. Fructose-2-SNAP and glucose-2-SNAP were synthesized and found to be much more cytotoxic than SNAP in killing DU-145 human prostate cancer cells in vitro.