Methylene blue reverts multidrug resistance: sensitivity of multidrug resistant cells to this dye and its photodynamic action

• Published in: Cancer letters Vol. 151; no. 2; pp. 161 - 167
• Main Authors: Trindade, G.S, Farias, S.L.A, Rumjanek, V.M, Capella, M.A.M
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 14.04.2000; Elsevier
• Subjects: Animals; Biological and medical sciences; Cell Division - drug effects; Cell Line; Cell Survival - drug effects; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; K562 Cells; Kidney - cytology; Kidney - drug effects; Leukemia, Erythroblastic, Acute - drug therapy; Leukemia, Erythroblastic, Acute - pathology; Medical sciences; Methylene blue; Methylene Blue - pharmacology; Methylene Blue - therapeutic use; Methylene Blue - toxicity; Multidrug resistance; P-glycoprotein; Phenotype; Photochemotherapy; Photodynamic action; Photoradiation therapy and photosensitizing agent; Treatment with physical agents; Treatment. General aspects; Tumors; Vincristine - pharmacology; P-glycoprotein; Photodynamic action; Multidrug resistance; Methylene blue; Cell proliferation; Cell culture; Photodynamic therapy; Toxicity; P Glycoprotein; Gene expression; In vitro; Substrate; Multiple resistance; Established cell line; Mechanism of action; Photooxidation; Tumor cell

Photodynamic action has been advocated as an alternative treatment of tumors but the most common used dyes, hematoporphyrin derivatives, are substrate for P-glycoprotein. This study investigated the MDR-reverting properties of methylene blue (MB) and compared the sensitivity to its photodynamic acti...