Methylene blue reverts multidrug resistance: sensitivity of multidrug resistant cells to this dye and its photodynamic action
Photodynamic action has been advocated as an alternative treatment of tumors but the most common used dyes, hematoporphyrin derivatives, are substrate for P-glycoprotein. This study investigated the MDR-reverting properties of methylene blue (MB) and compared the sensitivity to its photodynamic acti...
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Published in | Cancer letters Vol. 151; no. 2; pp. 161 - 167 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
14.04.2000
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Photodynamic action has been advocated as an alternative treatment of tumors but the most common used dyes, hematoporphyrin derivatives, are substrate for P-glycoprotein. This study investigated the MDR-reverting properties of methylene blue (MB) and compared the sensitivity to its photodynamic action (PDA) in five cell lines that either express or do not express the MDR phenotype. MB was able to revert the MDR phenotype and there was no difference in sensitivity to MB-PDA between MDR and non-MDR cells, suggesting that MB has the advantage of being used simultaneously as a MDR reverser and a photodynamic agent. |
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ISSN: | 0304-3835 1872-7980 |
DOI: | 10.1016/S0304-3835(99)00408-5 |