Investigating the effect of anticipating a startling acoustic stimulus on preparatory inhibition

• Published in: Neurophysiologie clinique Vol. 49; no. 2; pp. 137 - 147
• Main Authors: Grandjean, Julien, Quoilin, Caroline, Duque, Julie
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.04.2019; Elsevier Science Ltd
• Subjects: Action preparation; Corticospinal excitability; Double-coil; Impulse control; Impulsive behavior; Magnetic fields; Motor activity; Motor evoked potentials; Motor-evoked potential; Reaction time task; Transcranial magnetic stimulation; Corticospinal excitability; Transcranial magnetic stimulation; Action preparation; Impulse control; Motor-evoked potential; Double-coil
• ISSN: 0987-7053; 1769-7131
• DOI: 10.1016/j.neucli.2018.11.002

Motor-evoked potentials (MEPs) to transcranial magnetic stimulation (TMS) show a profound suppression when elicited during the instructed-delay of reaction time (RT) tasks. One predominant hypothesis is that this phenomenon, called “preparatory inhibition”, reflects the operation of processes that suppress motor activity to withhold prepared (but delayed) responses, a form of impulse control. In addition, a startling acoustic stimulus (SAS) – a loud and narrow sound – can trigger the release of prepared responses in RT tasks. We predicted that, if such premature release is clearly forbidden, then anticipating a SAS during delay periods may be associated with increased preparatory inhibition for greater impulse control. Subjects performed a behavioural (n=16) and TMS (n=11) experiment. Both used a choice RT task that required subjects to choose a response based on a preparatory cue but to only release it after an imperative signal. SAS and TMS pulses were elicited at the end of the delay period and subjects were asked to do their best to only release their response after the imperative signal, even in the presence of SAS. SAS could be either rare or frequent, in separate blocks. Consistent with the literature, SAS shortened RTs, especially when they occurred frequently. Moreover, MEPs were suppressed when subjects delayed prepared responses but this preparatory inhibition did not depend on whether SAS were frequent or rare. The stronger RT shortening with frequent rather than rare SAS may be due to increased attention and/or reduced reactive inhibition to SAS, leaving preparatory inhibition unaffected.