Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA

To evaluate the association between rheumatoid arthritis (RA)-related autoantibodies and plasma 25,OH vitamin D in subjects at risk for RA. In 1210 subjects without RA, 76 were positive for anti-cyclic citrullinated peptide antibodies or for at least 2 rheumatoid factors (RF; by nephelometry: RF-IgM...

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Bibliographic Details
Published inJournal of rheumatology Vol. 36; no. 5; p. 943
Main Authors Feser, Marie, Derber, Lezlie A, Deane, Kevin D, Lezotte, Dennis C, Weisman, Michael H, Buckner, Jane H, Mikuls, Ted, O'Dell, James, Gregersen, Peter K, Holers, V Michael, Norris, Jill M
Format Journal Article
LanguageEnglish
Published Canada 01.05.2009
Subjects
Adult
Arthritis, Rheumatoid - immunology
Biomarkers
Female
Humans
Immunoglobulins - immunology
Male
Middle Aged
Peptides, Cyclic - immunology
Rheumatoid Factor - immunology
Risk Factors
Vitamin D - analogs & derivatives
Vitamin D - blood
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Summary:To evaluate the association between rheumatoid arthritis (RA)-related autoantibodies and plasma 25,OH vitamin D in subjects at risk for RA. In 1210 subjects without RA, 76 were positive for anti-cyclic citrullinated peptide antibodies or for at least 2 rheumatoid factors (RF; by nephelometry: RF-IgM, RF-IgG, RF-IgA). 25,OH vitamin D was measured in these cases and 154 autoantibody-negative controls from this cohort. 25,OH vitamin D levels did not differ between cases and controls (adjusted OR 1.23, 95% CI 0.93-1.63). Vitamin D concentrations are not associated with RA-related autoimmunity in unaffected subjects at increased risk for RA.
ISSN:0315-162X
DOI:10.3899/jrheum.080764