Sweet’s syndrome associated with chronic myelogenous leukemia: Demonstration of leukemic cells within a skin lesion

We report a case of acute febrile neutrophilic dermatosis, Sweet’s syndrome, associated with chronic myelogenous leukemia (CML) in which we found rearrangement of the bcr gene in DNA obtained from a skin lesion as well as in blood DNA by Southern blot analysis. This indicated the presence of CML cel...

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Bibliographic Details
Published inJournal of the American Academy of Dermatology Vol. 40; no. 2; pp. 275 - 279
Main Authors Urano, Yoshio, Miyaoka, Yuki, Kosaka, Masaaki, Kabe, Kazuyuki, Uchida, Naoyuki, Arase, Seiji
Format Journal Article
LanguageEnglish
Published New York, NY Mosby, Inc 01.02.1999
Elsevier
Subjects
Biological and medical sciences
Blotting, Southern
Gene Rearrangement
Hand Dermatoses - genetics
Hand Dermatoses - pathology
Hematologic and hematopoietic diseases
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - blood
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Skin Neoplasms - genetics
Skin Neoplasms - pathology
Sweet Syndrome - complications
Case study
Human
Myeloproliferative syndrome
Skin disease
Chronic
Association
Chronic myelocytic leukemia
Malignant hemopathy
Acute febrile neutrophilic dermatosis
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Summary:We report a case of acute febrile neutrophilic dermatosis, Sweet’s syndrome, associated with chronic myelogenous leukemia (CML) in which we found rearrangement of the bcr gene in DNA obtained from a skin lesion as well as in blood DNA by Southern blot analysis. This indicated the presence of CML cells within the skin lesion. To our knowledge, this is the first report in which the presence of CML cells is shown within skin lesions of Sweet’s syndrome. In our patient, leukocyte alkaline phosphatase activities returned to normal levels when he was suffering from Sweet’s syndrome and decreased again to below normal levels after it subsided. Whether the normalization of leukocyte alkaline phosphatase activity is common among CML patients with Sweet’s syndrome remains to be determined. (J Am Acad Dermatol 1999;40:275-9.)
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ISSN:0190-9622
1097-6787
DOI:10.1016/S0190-9622(99)70206-9