A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis

• Published in: Life science alliance Vol. 2; no. 2; p. e201900355
• Main Authors: Wing, Peter AC, Davenne, Tamara, Wettengel, Jochen, Lai, Alvina G, Zhuang, Xiaodong, Chakraborty, Anindita, D’Arienzo, Valentina, Kramer, Catharina, Ko, Chunkyu, Harris, James M, Schreiner, Sabrina, Higgs, Martin, Roessler, Stephanie, Parish, Joanna L, Protzer, Ulrike, Balfe, Peter, Rehwinkel, Jan, McKeating, Jane A
• Format: Journal Article
• Language: English
• Published: United States Life Science Alliance LLC 01.04.2019
• Subjects: DNA, Circular - genetics; DNA, Viral - genetics; Gene Knockout Techniques; Hep G2 Cells; Hepatitis B virus - genetics; Hepatitis B, Chronic - enzymology; Hepatitis B, Chronic - virology; Humans; Reverse Transcription - genetics; RNA-Directed DNA Polymerase - genetics; SAM Domain and HD Domain-Containing Protein 1 - genetics; Transcriptional Activation; Transfection; Virus Replication - genetics

Chronic hepatitis B is one of the world’s unconquered diseases with more than 240 million infected subjects at risk of developing liver disease and hepatocellular carcinoma. Hepatitis B virus reverse transcribes pre-genomic RNA to relaxed circular DNA (rcDNA) that comprises the infectious particle....