ABCs of the lung microbiome

The lungs of healthy humans have traditionally been considered to be sterile when examined by culture-based techniques. However, molecular identification techniques are now being used to explore the lung microbiome in ways that mirror study of other body sites and organ systems. Familiarity with pop...

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Bibliographic Details
Published inAnnals of the American Thoracic Society Vol. 11 Suppl 1; no. 1; pp. S3 - S6
Main Author Beck, James M
Format Journal Article
LanguageEnglish
Published United States American Thoracic Society 01.01.2014
Subjects
Bronchoalveolar Lavage Fluid - microbiology
Humans
Lung - microbiology
Metagenome
Microbiota - genetics
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Summary:The lungs of healthy humans have traditionally been considered to be sterile when examined by culture-based techniques. However, molecular identification techniques are now being used to explore the lung microbiome in ways that mirror study of other body sites and organ systems. Familiarity with population definitions and indices of diversity will lead to better understanding of the literature now coming to publication. Differences in methodology and sampling may contribute significantly to experimental variability, and the field has not coalesced around standard ways to present data or to perform statistical comparisons. This emerging and exciting field of investigation is leading to new ways of thinking about the lung and about lung disease.
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ISSN:2329-6933
2325-6621
DOI:10.1513/AnnalsATS.201306-188MG