insomniac links the development and function of a sleep-regulatory circuit
Although many genes are known to influence sleep, when and how they impact sleep-regulatory circuits remain ill-defined. Here, we show that ( ), a conserved adaptor for the autism-associated Cul3 ubiquitin ligase, acts in a restricted period of neuronal development to impact sleep in adult . The los...
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Published in | eLife Vol. 10 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
eLife Sciences Publications Ltd
15.12.2021
eLife Sciences Publications, Ltd |
Subjects | |
Online Access | Get full text |
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Summary: | Although many genes are known to influence sleep, when and how they impact sleep-regulatory circuits remain ill-defined. Here, we show that
(
), a conserved adaptor for the autism-associated Cul3 ubiquitin ligase, acts in a restricted period of neuronal development to impact sleep in adult
. The loss of
causes structural and functional alterations within the mushroom body (MB), a center for sensory integration, associative learning, and sleep regulation. In
mutants, MB neurons are produced in excess, develop anatomical defects that impede circuit assembly, and are unable to promote sleep when activated in adulthood. Our findings link neurogenesis and postmitotic development of sleep-regulatory neurons to their adult function and suggest that developmental perturbations of circuits that couple sensory inputs and sleep may underlie sleep dysfunction in neurodevelopmental disorders. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Graduate Program in Molecular, Cellular, & Integrative Physiology, University of California, Los Angeles, United States. Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea. |
ISSN: | 2050-084X 2050-084X |
DOI: | 10.7554/eLife.65437 |