Genetic integration of behavioural and endocrine components of the stress response

• Published in: eLife Vol. 11
• Main Authors: Houslay, Thomas M, Earley, Ryan L, White, Stephen J, Lammers, Wiebke, Grimmer, Andrew J, Travers, Laura M, Johnson, Elizabeth L, Young, Andrew J, Wilson, Alastair
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 11.02.2022; eLife Sciences Publications, Ltd
• Subjects: animal behaviour; Animals; Behavior, Animal; Coping; coping styles; Evolutionary Biology; Female; Fresh Water - analysis; Genetic screening; Genetics and Genomics; Hormones; Hydrocortisone - analysis; Integration; Male; Natural selection; Physiology; Poecilia - genetics; Poecilia - physiology; poecilia reticulata; Quantitative genetics; Stress; Stress response; Stress, Psychological - genetics; Trout; quantitative genetics; stress; evolutionary biology; genetics; coping styles; animal behaviour; physiology; genomics; poecilia reticulata
• ISSN: 2050-084X; 2050-084X
• DOI: 10.7554/ELIFE.67126

The vertebrate stress response comprises a suite of behavioural and physiological traits that must be functionally integrated to ensure organisms cope adaptively with acute stressors. Natural selection should favour functional integration, leading to a prediction of genetic integration of these traits. Despite the implications of such genetic integration for our understanding of human and animal health, as well as evolutionary responses to natural and anthropogenic stressors, formal quantitative genetic tests of this prediction are lacking. Here, we demonstrate that acute stress response components in Trinidadian guppies are both heritable and integrated on the major axis of genetic covariation. This integration could either facilitate or constrain evolutionary responses to selection, depending upon the alignment of selection with this axis. Such integration also suggests artificial selection on the genetically correlated behavioural responses to stress could offer a viable non-invasive route to the improvement of health and welfare in captive animal populations.