High circulating levels of the IL-1 type II decoy receptor in critically ill patients with sepsis: association of high decoy receptor levels with glucocorticoid administration

The objective of this study was to evaluate whether the interleukin (IL)‐1 decoy receptor (R), a negative pathway of regulation of IL‐1, is correlated with severity of infection in critically ill patients and reflects the activation of anti‐inflammatory pathways by glucocorticoid hormones. Plasma sa...

Full description

Saved in:
Bibliographic Details
Published inJournal of leukocyte biology Vol. 72; no. 4; pp. 643 - 649
Main Authors Müller, Beat, Peri, Giuseppe, Doni, Andrea, Perruchoud, André P., Landmann, Regine, Pasqualini, Fabio, Mantovani, Alberto
Format Journal Article
LanguageEnglish
Published United States Society for Leukocyte Biology 01.10.2002
Subjects
Anti-Inflammatory Agents - therapeutic use
Critical Illness
cytokines
glucocorticoid hormones
Glucocorticoids - therapeutic use
Humans
Intensive Care Units
microbial infection
Prednisone - therapeutic use
Receptors, Interleukin-1 - blood
Sepsis - blood
severe sepsis
Online AccessGet full text

Cover

More Information
Summary:The objective of this study was to evaluate whether the interleukin (IL)‐1 decoy receptor (R), a negative pathway of regulation of IL‐1, is correlated with severity of infection in critically ill patients and reflects the activation of anti‐inflammatory pathways by glucocorticoid hormones. Plasma samples were obtained from 101 consecutive, critically ill patients admitted to the intensive care unit with different severities of microbial infection, as defined by standardized criteria. Here, we report that the IL‐1 type II decoy R(II) is elevated in critically ill patients, especially in severe, systemic infection and culture‐positive infections. In patients with a marked systemic inflammatory response syndrome 4, a pronounced, sepsis‐induced further increase of circulating IL‐1 decoy RII levels was evident. Thirty‐six patients treated with glucocorticoid hormones had significantly higher levels of IL‐1 decoy RII, but lower IL‐6 and C‐reactive protein, than 67 untreated subjects. The usefulness of IL‐1RII, in particular as a potential marker for the activation of anti‐inflammatory pathways or for responsiveness to anti‐inflammatory agents such as glucocorticoid hormones, deserves further analysis.
Bibliography:B. M. and G. P. contributed equally to this work.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0741-5400
1938-3673
DOI:10.1189/jlb.72.4.643