IN VITRO STUDIES WITH CEFAZAFLUR AND OTHER PARENTERAL CEPHALOSPORINS

Cefazaflur has a broad-spectrum of in vitro antibacterial activity equal to or greater than that of the commercially-available cephalosporins. In addition, cefazaflur has activity against isolates of Enterobacter, Citrobacter and indole-positive Proteus; however, this activity decreased markedly whe...

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Published inJournal of antibiotics Vol. 30; no. 9; pp. 730 - 735
Main Authors ACTOR, PAUL, GUARINI, JOSEPH R., URI, JOSEPH, BARTUS, HENRY F., ZAJAC, IHOR, WEISBACH, JERRY A.
Format Journal Article
LanguageEnglish
Published Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1977
Subjects
Bacteria - drug effects
Cephalosporins - blood
Cephalosporins - pharmacology
Humans
Penicillin Resistance
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Summary:Cefazaflur has a broad-spectrum of in vitro antibacterial activity equal to or greater than that of the commercially-available cephalosporins. In addition, cefazaflur has activity against isolates of Enterobacter, Citrobacter and indole-positive Proteus; however, this activity decreased markedly when the MIC determinations were carried out with a large inoculum size. A similar inoculum effect was observed with cefamandole, however, cefoxitin's activity was relatively unchanged at increased inoculum sizes. Human serum had a relatively small effect on the in vitro activity of cefazaflur.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.30.730